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Gene and Protein Information | ||||||
class A G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 360 | 1p36.11 | CNR2 | cannabinoid receptor 2 | 42,56 |
Mouse | 7 | 347 | 4 D3 | Cnr2 | cannabinoid receptor 2 | 58 |
Rat | 7 | 360 | 5q36 | Cnr2 | cannabinoid receptor 2 | 9 |
Previous and Unofficial Names |
rCB2 | cannabinoid receptor 2 (spleen) | CB2-R | Peripheral cannabinoid receptor | cannabinoid receptor 2 (macrophage) |
Database Links | |
Specialist databases | |
GPCRdb | cnr2_human (Hs), cnr2_mouse (Mm), cnr2_rat (Rn) |
Other databases | |
Alphafold | P34972 (Hs), P47936 (Mm), Q9QZN9 (Rn) |
ChEMBL Target | CHEMBL253 (Hs), CHEMBL5373 (Mm), CHEMBL2470 (Rn) |
DrugBank Target | P34972 (Hs) |
Ensembl Gene | ENSG00000188822 (Hs), ENSMUSG00000062585 (Mm), ENSRNOG00000009260 (Rn) |
Entrez Gene | 1269 (Hs), 12802 (Mm), 57302 (Rn) |
Human Protein Atlas | ENSG00000188822 (Hs) |
KEGG Gene | hsa:1269 (Hs), mmu:12802 (Mm), rno:57302 (Rn) |
OMIM | 605051 (Hs) |
Pharos | P34972 (Hs) |
RefSeq Nucleotide | NM_001841 (Hs), NM_009924 (Mm), NM_020543 (Rn) |
RefSeq Protein | NP_001832 (Hs), NP_034054 (Mm), NP_065418 (Rn) |
UniProtKB | P34972 (Hs), P47936 (Mm), Q9QZN9 (Rn) |
Wikipedia | CNR2 (Hs) |
Natural/Endogenous Ligands |
anandamide |
2-arachidonoylglycerol |
Comments: Endogenous ligands include other endocannabinoids |
Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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The higher pKi value for anandamide (6.43) was determined in the presence of phenylmethylsulfonyl fluoride to prevent enzymic hydrolysis. For reviews, see references [28,45-46] |
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Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
CB2 receptor on eosinophils mainly mediates anti-inflammatory and immunomodulatory actions e.g. downregulation of pro-inflammatory mediator release. Pharmacological targeting with the CB2 receptor selective antagonist SR144528 attenuates the recruitment of eosinophils and ear swelling in a murine chronic contact dermatitis model [44]. |
Cell Type Associations | ||||||||
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Primary Transduction Mechanisms | |
Transducer | Effector/Response |
Gi/Go family |
Adenylyl cyclase inhibition Other - See Comments |
Comments: Activation of MAP kinase leading to immediate early gene expression[28,57]. | |
References: 8-9,17,28,58-60 |
Secondary Transduction Mechanisms | |
Transducer | Effector/Response |
Gs family | Adenylyl cyclase stimulation |
References: 28,49 |
Tissue Distribution | ||||||||
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Expression Datasets | |
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Physiological Consequences of Altering Gene Expression | ||||||||||
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Phenotypes, Alleles and Disease Models | Mouse data from MGI | ||||||||||||||||||
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General Comments |
Techniques used include Northern blot, in situ hybridization and receptor autoradiography[28,45] |
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