Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	1696		api-IRS	isoleucine--tRNA ligase, putative
Gene and Protein Information Comments
The Plasmodium genome encodes two forms of isoleucyl-tRNA synthetase, one found in the cytoplasm (PfcIRS, encoded by PF3D7_1332900) and one in the apicoplast (PfaIRS, described here).

Previous and Unofficial Names

Pf3D7_12_v3:1,018,351..1,024,017(+) | Pfapi-IRS | PFL1210w | Plasmodium falciparum isoleucine--tRNA ligase

Database Links
Alphafold	Q8I5G6 (Pf3D7)
PlasmoDB	PF3D7_1225100 (Pf3D7)
UniProtKB	Q8I5G6 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference mupirocin Pf3D7 Plasmodium falciparum 3D7 P. falciparum strain 3D7 (Pf3D7) was derived from isolate NF54 by limiting dilution. The complete genome of Pf3D7 has been sequenced (GenBank: LN999946.1). Pf3D7 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ - - 7.2 pIC50 1 ⤷ pIC50 7.2 (IC50 5.74x10-8 M) [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Malaria Pharmacology Comments

P. falciparum isoleucyl-tRNA synthetase pairs isoleucine with its cognate tRNA and is categorized as a class I aaRS.