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The aminoacyl-tRNA synthetases (aaRSs) are a large and diverse enzyme family with an essential role in the ATP-dependent aminoacylation of cognate tRNAs with their respective amino acids for use in protein synthesis [2]. The P. falciparum genome encodes 36 different aaRSs, which participate in both cytoplasmic and organellar protein synthesis and are emerging targets for antimalarial agents [1,3].
PfaIRS (Plasmodium falciparum isoleucyl-tRNA synthetase)
C
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PfcKRS (Plasmodium falciparum lysyl-tRNA synthetase)
C
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PfcFRS (Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit)
C
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PfcPRS (Plasmodium falciparum prolyl-tRNA synthetase)
C
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PfTRS (Plasmodium falciparum threonyl-tRNA synthetase)
C
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PfaWRS (Plasmodium falciparum tryptophanyl-tRNA synthetase)
C
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Database page citation:
Aminoacyl-tRNA synthetases. Accessed on 08/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.