Top ▲

Aminoacyl-tRNA synthetases

Overview

Click here for help

« Hide

The aminoacyl-tRNA synthetases (aaRSs) are emerging targets for antimalarial agents [1]. Although sharing a common tRNA esterification catalytic activity, these proteins are structurally diverse and physiologically distinct enzymes.

Targets

Click here for help

Pfapi-IRS (Plasmodium falciparum isoleucine--tRNA ligase) C Show summary » More detailed page go icon to follow link

PfKRS1 (Plasmodium falciparum lysine--tRNA ligase) C Show summary » More detailed page go icon to follow link

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) C Show summary » More detailed page go icon to follow link

PfPRS (Plasmodium falciparum proline--tRNA ligase) C Show summary » More detailed page go icon to follow link

PfThrRS (Plasmodium falciparum threonine--tRNA ligase) C Show summary » More detailed page go icon to follow link

PfaTrpRS (Plasmodium falciparum tryptophan--tRNA ligase) C Show summary » More detailed page go icon to follow link

References

Click here for help

Show »

How to cite this family page

Database page citation:

Aminoacyl-tRNA synthetases. Accessed on 19/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.