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Aminoacyl-tRNA synthetases

Overview

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The aminoacyl-tRNA synthetases (aaRSs) are a large and diverse enzyme family with an essential role in the ATP-dependent aminoacylation of cognate tRNAs with their respective amino acids for use in protein synthesis [2]. The P. falciparum genome encodes 36 different aaRSs, which participate in both cytoplasmic and organellar protein synthesis and are emerging targets for antimalarial agents [1,3].

Targets

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PfaIRS (Plasmodium falciparum isoleucyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfcKRS (Plasmodium falciparum lysyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfcFRS (Plasmodium falciparum phenylalanyl-tRNA synthetase alpha subunit) C Show summary » More detailed page go icon to follow link

PfcPRS (Plasmodium falciparum prolyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfTRS (Plasmodium falciparum threonyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

PfaWRS (Plasmodium falciparum tryptophanyl-tRNA synthetase) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Aminoacyl-tRNA synthetases. Accessed on 24/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1050.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.