Top ▲

Plasmodium falciparum isoleucine--tRNA ligase

Click here for help

Target id: 3168

Nomenclature: Plasmodium falciparum isoleucine--tRNA ligase

Abbreviated Name: PfaIRS

Family: Aminoacyl-tRNA synthetases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1696 api-IRS isoleucine--tRNA ligase, putative
Gene and Protein Information Comments
The Plasmodium genome encodes two forms of isoleucine--tRNA ligase, one found in the cytoplasm (PfcIRS, encoded by PF3D7_1332900) and one in the apicoplast (PfaIRS, described here).
Previous and Unofficial Names Click here for help
Pfapi-IRS | PFL1210w | Plasmodium falciparum isoleucyl-tRNA synthetase
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
mupirocin Small molecule or natural product Approved drug Guide to Malaria Pharmacology Ligand Pf3D7 - - 7.2 pIC50 1
pIC50 7.2 (IC50 5.74x10-8 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
P. falciparum isoleucine--tRNA ligase pairs isoleucine with its cognate tRNA and is categorized as a class I aaRS.

References

Show »

1. Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. (2011) Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A, 108 (4): 1627-32. [PMID:21205898]

How to cite this page

Aminoacyl-tRNA synthetases: Plasmodium falciparum isoleucine--tRNA ligase. Last modified on 11/12/2021. Accessed on 21/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3168.