Top ▲

C-type lectin domain family 4 member A

Click here for help

Target id: 2931

Nomenclature: C-type lectin domain family 4 member A

Abbreviated Name: DCIR

Family: C-type lectin-like receptors (CLRs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 237 12p13.31 CLEC4A C-type lectin domain family 4 member A 1
Mouse 1 238 6 58.18 cM Clec4a2 C-type lectin domain family 4, member a2
Rat 1 237 4q42 Clec4a3 C-type lectin domain family 4
Gene and Protein Information Comments
Variants encoding shorter isoforms of human DCIR are reported. Two splice variants of the mouse gene encode identical shorter protein isoforms, compared to isoform 1 presented here..
Previous and Unofficial Names Click here for help
CD367 | CLECSF6 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 | Dendritic cell (DC) immunoreceptor (IR) | C-type lectin domain family 4, member A3 | C-type lectin domain family 4, member a2 | C-type lectin domain family 4
Database Links Click here for help
Alphafold Q9UMR7 (Hs), Q9QZ15 (Mm)
CATH/Gene3D 3.10.100.10
Ensembl Gene ENSG00000111729 (Hs), ENSMUSG00000030148 (Mm), ENSRNOG00000010018 (Rn)
Entrez Gene 50856 (Hs), 26888 (Mm), 362431 (Rn)
Human Protein Atlas ENSG00000111729 (Hs)
KEGG Gene hsa:50856 (Hs), mmu:26888 (Mm), rno:362431 (Rn)
OMIM 605306 (Hs)
Pharos Q9UMR7 (Hs)
RefSeq Nucleotide NM_016184 (Hs), NM_001170333 (Mm), NM_001005891 (Rn)
RefSeq Protein NP_057268 (Hs), NP_001163804 (Mm), NP_001005891 (Rn)
UniProtKB Q9UMR7 (Hs), Q9QZ15 (Mm)
Wikipedia CLEC4A (Hs)
Immunopharmacology Comments
CLEC4A is an pattern recognition receptor and immunoreceptor that functions in cell adhesion, cell-cell signalling, glycoprotein turnover, and plays roles in inflammation and the immune response. It contains a immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain.
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
References:  1
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0061760 antifungal innate immune response IBA
Immuno Process:  Immune regulation
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0002470 plasmacytoid dendritic cell antigen processing and presentation IDA
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0001818 negative regulation of cytokine production IDA
GO:0032720 negative regulation of tumor necrosis factor production IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0036037 CD8-positive, alpha-beta T cell activation IDA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0036037 CD8-positive, alpha-beta T cell activation IDA
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002250 adaptive immune response IEA

References

Show »

1. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S et al.. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol, 163 (4): 1973-83. [PMID:10438934]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member A. Last modified on 16/07/2020. Accessed on 04/10/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2931.