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Non-catalytic pattern recognition receptors

Contents

Overview

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This section concentrates on those pattern recognition receptors (PRRs) encoded by the human genome which are non-catalytic DNA-sensing proteins. Like other PRRs, these proteins facilitate the induction of an innate immune response upon detection of pathogens, via a variety of signalling pathways.

Catalytic receptor PRRs included in the Guide To PHARMACOLOGY are:
Toll-like receptors (TLRs)
Nucleotide-binding oligomerization domain-like receptors (NLRs, also known as NOD-like receptors), and
RIG-I-like receptors (RLRs)

Subfamilies

How to cite this family page

Database page citation:

Non-catalytic pattern recognition receptors. Accessed on 25/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=941.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.