C-type lectin-like receptors (CLRs)

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C-type lectin-like receptors (CLRs)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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C-type lectin-like receptors are single-pass type II membrane proteins involved widely in the recognition of pathogens and initiation of the innate response to maintain immune homeostasis [1-2].

Targets

DCIR (C-type lectin domain family 4 member A) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2931
Nomenclature	C-type lectin domain family 4 member A
Common abbreviation	DCIR
Previous and unofficial names	CD367 \| CLECSF6 \| C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 \| Dendritic cell (DC) immunoreceptor (IR) \| C-type lectin domain family 4, member A3 \| C-type lectin domain family 4, member a2 \| C-type lectin domain family 4
Genes	CLEC4A (Hs), Clec4a2 (Mm), Clec4a3 (Rn)
Ensembl ID	ENSG00000111729 (Hs), ENSMUSG00000030148 (Mm), ENSRNOG00000010018 (Rn)
UniProtKB AC	Q9UMR7 (Hs), Q9QZ15 (Mm)

BDCA2 (C-type lectin domain family 4 member C) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3135
Nomenclature	C-type lectin domain family 4 member C
Common abbreviation	BDCA2
Previous and unofficial names	C-type lectin domain family 4, member B2 \| C-type lectin domain family 4 \| C-type lectin domain family 4, member b1 \| BDCA2 \| Blood dendritic cell antigen 2 \| CD303 \| Dendritic lectin \| DLEC \| BDCA-2
Genes	CLEC4C (Hs), Clec4b1 (Mm), Clec4b2 (Rn)
Ensembl ID	ENSG00000198178 (Hs), ENSMUSG00000030147 (Mm), ENSRNOG00000027655 (Rn)
UniProtKB AC	Q8WTT0 (Hs)

DC-SIGN (CD209 molecule) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2930
Nomenclature	CD209 molecule
Common abbreviation	DC-SIGN
Previous and unofficial names	CDSIGN \| CLEC4L
Genes	CD209 (Hs)
Ensembl ID	ENSG00000090659 (Hs)
UniProtKB AC	Q9NNX6 (Hs)

Dectin-1 (C-type lectin domain family 7 member A) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2927
Nomenclature	C-type lectin domain family 7 member A
Common abbreviation	Dectin-1
Previous and unofficial names	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 \| CLECSF12 \| CD369 \| SCARE2 \| Beta-glucan receptor BGR \| Dendritic cell-associated C-type lectin 1 \| C-type lectin domain family 7, member A \| C-type lectin domain family 7, member a \| C-type lectin domain family 7
Genes	CLEC7A (Hs), Clec7a (Mm), Clec7a (Rn)
Ensembl ID	ENSG00000172243 (Hs), ENSMUSG00000079293 (Mm), ENSRNOG00000054251 (Rn)
UniProtKB AC	Q9BXN2 (Hs), Q6QLQ4 (Mm)

Dectin-2 (C-type lectin domain family 6 member A) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2928
Nomenclature	C-type lectin domain family 6 member A
Common abbreviation	Dectin-2
Previous and unofficial names	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 \| CLECSF10 \| CLEC4N \| C-type lectin domain family 4, member n \| C-type lectin domain family 4
Genes	CLEC6A (Hs), Clec4n (Mm)
Ensembl ID	ENSG00000205846 (Hs), ENSMUSG00000023349 (Mm)
UniProtKB AC	Q6EIG7 (Hs), Q9JKF4 (Mm)

Mincle (C-type lectin domain family 4 member E) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2929
Nomenclature	C-type lectin domain family 4 member E
Common abbreviation	Mincle
Previous and unofficial names	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 \| CLECSF9 \| Macrophage-inducible C-type lectin \| C-type lectin domain family 4, member E \| C-type lectin domain family 4, member e \| C-type lectin domain family 4
Genes	CLEC4E (Hs), Clec4e (Mm), Clec4e (Rn)
Ensembl ID	ENSG00000166523 (Hs), ENSMUSG00000030142 (Mm), ENSRNOG00000061394 (Rn)
UniProtKB AC	Q9ULY5 (Hs), Q9R0Q8 (Mm), Q67EQ1 (Rn)

C-type lectin domain family 12 member A / CD371 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3081
Nomenclature	C-type lectin domain family 12 member A
Systematic nomenclature	CD371
Previous and unofficial names	C-type lectin domain family 12, member A \| C-type lectin domain family 12, member a \| C-type lectin domain family 12 \| CLL-1 \| dendritic cell-associated lectin 2 \| DCAL-2 \| myeloid inhibitory C-type lectin-like receptor \| MICL
Genes	CLEC12A (Hs), Clec12a (Mm), Clec12a (Rn)
Ensembl ID	ENSG00000172322 (Hs), ENSMUSG00000053063 (Mm), ENSRNOG00000054860 (Rn)
UniProtKB AC	Q5QGZ9 (Hs), Q504P2 (Mm)

References

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How to cite this family page

Database page citation:

C-type lectin-like receptors (CLRs). Accessed on 27/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=945.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.