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C-type lectin domain family 4 member E

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Target id: 2929

Nomenclature: C-type lectin domain family 4 member E

Abbreviated Name: Mincle

Family: C-type lectin-like receptors (CLRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 219 12p13.31 CLEC4E C-type lectin domain family 4 member E
Mouse 1 214 6 58.35 cM Clec4e C-type lectin domain family 4, member e
Rat 1 215 4q42 Clec4e C-type lectin domain family 4, member E
Previous and Unofficial Names Click here for help
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 | CLECSF9 | Macrophage-inducible C-type lectin | C-type lectin domain family 4, member E | C-type lectin domain family 4, member e | C-type lectin domain family 4
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GlcC14C18 Small molecule or natural product Immunopharmacology Ligand Hs Agonist ~10.0 pEC50 2
pEC50 ~10.0 (EC50 ~1x10-10 M) [2]
Description: Measuring activation of an NF-κB reporter in HEK293 cells expressing human mincle.
Immunopharmacology Comments
Mincle is an FcRγ-associated membrane receptor involved in initiating the innate immune response upon recognition of endogenous and exogenous ligands including Sin3A-associated protein (SAP130), α-mannan on fungal cell walls and mycobacterial cord factor (trehalose-6,6′-dimycolate (TDM)) [1]. Mincle signals to NF-κB via the Syk-Card9-Bcl10-Malt1 pathway and induces a robust Th1 and Th17 response. Mincle is being targeted pharmacologically in an attempt to produce novel vaccine adjuvants that enhance cell-mediated immune responses [2]- in this case based on the immunogenicity of TDM.
Mincle's role in human B cell responses was investigated in [3].
Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
References:  3
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   neutrophil (CL:0000775)
References:  3
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
Immuno Cell Type:  Macrophages & monocytes
Cell Ontology Term:   macrophage (CL:0000235)
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  T cell (activation)
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
General Comments
Mincle is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).


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1. Bryant CE, Orr S, Ferguson B, Symmons MF, Boyle JP, Monie TP. (2015) International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev, 67 (2): 462-504. [PMID:25829385]

2. Decout A, Silva-Gomes S, Drocourt D, Barbe S, André I, Cueto FJ, Lioux T, Sancho D, Pérouzel E, Vercellone A et al.. (2017) Rational design of adjuvants targeting the C-type lectin Mincle. Proc Natl Acad Sci USA, 114 (10): 2675-2680. [PMID:28223515]

3. Kawata K, Illarionov P, Yang GX, Kenny TP, Zhang W, Tsuda M, Ando Y, Leung PS, Ansari AA, Eric Gershwin M. (2012) Mincle and human B cell function. J Autoimmun, 39 (4): 315-22. [PMID:22698596]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member E. Last modified on 16/05/2017. Accessed on 25/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,