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C-type lectin domain family 6 member A

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Target id: 2928

Nomenclature: C-type lectin domain family 6 member A

Abbreviated Name: Dectin-2

Family: C-type lectin-like receptors (CLRs)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 209 12p13.31 CLEC6A C-type lectin domain containing 6A
Mouse 1 209 6 58.3 cM Clec4n C-type lectin domain family 4, member n
Gene and Protein Information Comments
A shorter transcript and protein isoform of human the CLEC6A gene have been reported [1]. Two alternative transcripts and protein isoforms arising from the mouse gene have been identified. A rat homolog of human CLEC6A has not been identified.
Previous and Unofficial Names Click here for help
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 | CLECSF10 | CLEC4N | C-type lectin domain family 4, member n | C-type lectin domain family 4
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
Dectin-2 is involved in initiating the innate immune response upon recognition of high mannose structures on fungal cell walls. It associates with the ITAM-containing FcRβ adaptor and signals through the Syk, PKCδ, and CARD9-Bcl10-MALT1 pathways to promote cytokine production in response to fungal infection.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
General Comments
Dectin-2 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).


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1. Gavino AC, Chung JS, Sato K, Ariizumi K, Cruz Jr PD. (2005) Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2. Exp Dermatol, 14 (4): 281-8. [PMID:15810886]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 6 member A. Last modified on 20/03/2017. Accessed on 13/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,