Quaternary Structure: Subunits

Interleukin-7 receptor subunit α (Ligand-binding subunit)

Cytokine receptor-like factor 2 (Other subunit)

Natural/Endogenous Ligands
thymic stromal lymphopoietin {Sp: Human}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference thymic stromal lymphopoietin {Sp: Human} Hs Agonist - - ⤷

Immunopharmacology Comments

TLSP/TLSPR signalling promotes release of pro-inflammatory Th2 mediators by mast cells and eosinophils [3], enhances eosinophil chemotaxis and pro-survival properties [4], and modulates mast cell proliferation and differentiation from progenitors [2]. No progress of therapeutic targeting of this receptor has been reported.

Cell Type Associations

Immuno Cell Type:  Granulocytes Cell Ontology Term:   eosinophil (CL:0000771) Comment:  TLSP receptors have been detected on eosiniphils by mRNA expression and flow cytometry. References:  1

Immuno Cell Type:  Mast cells Cell Ontology Term:   mast cell (CL:0000097) Comment:  Functional TLSP receptors are reported on the surface of mast cells. References:  3