Thymic stromal lymphopoietin receptor | IL-2 receptor family | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Thymic stromal lymphopoietin receptor

Target id: 2305

Nomenclature: Thymic stromal lymphopoietin receptor

Family: IL-2 receptor family

Quaternary Structure: Subunits
Interleukin-7 receptor subunit α (Ligand-binding subunit)
Cytokine receptor-like factor 2 (Other subunit)
Natural/Endogenous Ligands
thymic stromal lymphopoietin {Sp: Human}

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Ligand Sp. Action Value Parameter Reference
thymic stromal lymphopoietin {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
TLSP/TLSPR signalling promotes release of pro-inflammatory Th2 mediators by mast cells and eosinophils [3], enhances eosinophil chemotaxis and pro-survival properties [4], and modulates mast cell proliferation and differentiation from progenitors [2]. No progress of therapeutic targeting of this receptor has been reported.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
Comment:  TLSP receptors have been detected on eosiniphils by mRNA expression and flow cytometry.
References:  1
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Comment:  Functional TLSP receptors are reported on the surface of mast cells.
References:  3


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1. Cook EB, Stahl JL, Schwantes EA, Fox KE, Mathur SK. (2012) IL-3 and TNF╬▒ increase Thymic Stromal Lymphopoietin Receptor (TSLPR) expression on eosinophils and enhance TSLP-stimulated degranulation. Clin Mol Allergy, 10 (1): 8. [PMID:22838633]

2. Han NR, Oh HA, Nam SY, Moon PD, Kim DW, Kim HM, Jeong HJ. (2014) TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6. J. Invest. Dermatol., 134 (10): 2521-30. [PMID:24751726]

3. Migalovich-Sheikhet H, Friedman S, Mankuta D, Levi-Schaffer F. (2012) Novel identified receptors on mast cells. Front Immunol, 3: 238. [PMID:22876248]

4. Wong CK, Hu S, Cheung PF, Lam CW. (2010) Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation. Am. J. Respir. Cell Mol. Biol., 43 (3): 305-15. [PMID:19843704]

How to cite this page

IL-2 receptor family: Thymic stromal lymphopoietin receptor. Last modified on 10/04/2017. Accessed on 20/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,