Top ▲

Cytokine receptor-like factor 2

Click here for help

Target id: 1704

Nomenclature: Cytokine receptor-like factor 2

Family: IL-2 receptor family

Contents:

Quaternary Structure: Complexes
Thymic stromal lymphopoietin receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 371 Xp22.3 and Yp11.3 CRLF2 cytokine receptor like factor 2
Mouse 1 359 5 F Crlf2 cytokine receptor-like factor 2
Rat 1 360 14p22 Crlf2 cytokine receptor-like factor 2
Previous and Unofficial Names Click here for help
thymic stromal lymphopoietin protein receptor | Tpte2 | TSLP receptor | Ly114 | CRL2 | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Database Links Click here for help
Alphafold Q9HC73 (Hs), Q8CII9 (Mm), Q8R4S8 (Rn)
CATH/Gene3D 2.60.40.10
Ensembl Gene ENSG00000205755 (Hs), ENSMUSG00000033467 (Mm), ENSRNOG00000049828 (Rn)
Entrez Gene 64109 (Hs), 57914 (Mm), 171499 (Rn)
Human Protein Atlas ENSG00000205755 (Hs)
KEGG Gene hsa:64109 (Hs), mmu:57914 (Mm), rno:171499 (Rn)
OMIM 300357 (Hs)
Pharos Q9HC73 (Hs)
UniProtKB Q9HC73 (Hs), Q8CII9 (Mm), Q8R4S8 (Rn)
Wikipedia CRLF2 (Hs)
Immunopharmacology Comments
Cytokine receptor-like factor 2 is the signal transducing subunit of the functional heterodimeric receptor for thymic stromal lymphopoietin (TSLP). Ligand binding is attributed to the interleukin-7 receptor subunit α.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0004923 leukemia inhibitory factor receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0032754 positive regulation of interleukin-5 production IMP
click arrow to show/hide IEA associations
GO:0038165 oncostatin-M-mediated signaling pathway IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP

How to cite this page

IL-2 receptor family: Cytokine receptor-like factor 2. Last modified on 10/04/2017. Accessed on 08/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1704.