Interleukin-7 receptor subunit α

Target id: 1698

Nomenclature: Interleukin-7 receptor subunit α

Quaternary Structure: Complexes
Interleukin-7 receptor
Thymic stromal lymphopoietin receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	459	5p13.2	IL7R	interleukin 7 receptor
Mouse	1	459	15 4.16 cM	Il7r	interleukin 7 receptor
Rat	-	-		Il7r	interleukin 7 receptor

Previous and Unofficial Names
CD127 \| interleukin-7 receptor subunit alpha \| IL-7 receptor alpha chain

Database Links
Alphafold	P16871 (Hs), P16872 (Mm)
CATH/Gene3D	2.60.40.10
Ensembl Gene	ENSG00000168685 (Hs), ENSMUSG00000003882 (Mm), ENSRNOG00000065741 (Rn)
Entrez Gene	3575 (Hs), 16197 (Mm), 294797 (Rn)
Human Protein Atlas	ENSG00000168685 (Hs)
KEGG Gene	hsa:3575 (Hs), mmu:16197 (Mm), rno:294797 (Rn)
OMIM	146661 (Hs)
Pharos	P16871 (Hs)
UniProtKB	P16871 (Hs), P16872 (Mm)
Wikipedia	IL7R (Hs)

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Antibodies

Key to terms and symbols

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Antibody		Sp.	Action	Value	Parameter	Reference
lusvertikimab		Hs	Antagonist	~11.4	pEC₅₀	3
⤷	pEC₅₀ ~11.4 (EC₅₀ ~4x10^-12 M) [3] Description: In an ELISA binding assay.
bempikibart		Hs	Binding	8.7 – 9.0	pEC₅₀	6
⤷	pEC₅₀ 8.7 – 9.0 (EC₅₀ 2x10^-9 – 1x10^-9 M) [6] Description: Binding potency for IL-7 receptor on isolated human CD8+ve T cells

Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-7 receptor complex. Effimmune are developing anti-IL7Rα monoclonal antibodies (e.g. OSE-127 [3]) with the objective of suppressing inflammation in T cell-mediated chronic inflammatory diseases. This team have reported that anti-IL7Rα monoclonals with exclusively antagonistic activity are efficacious in a non-human primate chronic skin inflammation model, and that the response is characterised by a sustained blunting of antigen-specific memory T cell activity [1].

Immunopharmacology Comments

This is the ligand binding subunit of the functional IL-7 receptor complex.
Effimmune are developing anti-IL7Rα monoclonal antibodies (e.g. OSE-127 [3]) with the objective of suppressing inflammation in T cell-mediated chronic inflammatory diseases. This team have reported that anti-IL7Rα monoclonals with exclusively antagonistic activity are efficacious in a non-human primate chronic skin inflammation model, and that the response is characterised by a sustained blunting of antigen-specific memory T cell activity [1].

Cell Type Associations

Immuno Cell Type:	T cells
Cell Ontology Term:	effector T cell (CL:0000911)
Comment:	IL-7RA (CD127) is expressed on T_effcells, and is involved in the development and persistence of chronic colitis [5].
References:	2,4

References

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1. Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E et al.. (2018) IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates. Nat Commun, 9 (1): 4483. [PMID:30367166]

2. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B et al.. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med, 203 (7): 1701-11. [PMID:16818678]

3. Poirier N, Mary C, Vanhove B. (2015) Antibodies directed against CD127. Patent number: WO2015189302. Assignee: Effimune. Priority date: 10/06/2014. Publication date: 17/12/2015.

4. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R et al.. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med, 203 (7): 1693-700. [PMID:16818676]

5. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. (2011) Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol, 186 (4): 2623-32. [PMID:21217010]

6. Yamniuk AP, Brodeur SR, Deyanova E, Huang RYC, Wang Y, Langish Ar, Chen G, Carl SM, Shen H, Pashine AM et al.. (2020) Antibodies against il-7r alpha subunit and uses thereof. Patent number: WO2020154293A1. Assignee: Bristol-Myers Squibb Company. Priority date: 21/01/2020. Publication date: 30/07/2020.

How to cite this page

IL-2 receptor family: Interleukin-7 receptor subunit α. Last modified on 12/02/2025. Accessed on 26/03/2026. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1698.

Interleukin-7 receptor subunit α

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References

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