Quaternary Structure: Subunits

Interleukin-12 receptor, β1 subunit (Ligand-binding subunit)

Interleukin-12 receptor, β2 subunit (Other subunit)

Natural/Endogenous Ligands
IL-12 {Sp: Human}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference IL-12 {Sp: Human} Hs Agonist - - ⤷

Immunopharmacology Comments

This is the type I cytokine receptor for interleukin 12 (IL-12). It is a heterodimeric receptor formed by IL-12R-β1 (IL12RB1; ligand binding subunit) and IL-12R-β2 (IL12RB2). IL-12R signals via the JAK-STAT pathway. IL-12 receptor activation promotes the development of Th1 responses and induces IFNγ production by T and NK cells. Patients with inactive IL-12 receptors exhibit impaired mycobacterial immunity, with a failure to produce an IFNγ response to IL-12 [1].