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Interleukin-12 receptor, β1 subunit

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Target id: 1715

Nomenclature: Interleukin-12 receptor, β1 subunit

Family: IL-12 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-12 receptor
Interleukin-23 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 662 19p13.11 IL12RB1 interleukin 12 receptor subunit beta 1
Mouse 1 738 8 34.21 cM Il12rb1 interleukin 12 receptor, beta 1
Rat - - Il12rb1 interleukin 12 receptor subunit beta 1
Previous and Unofficial Names Click here for help
CD212 | interleukin 12 receptor, beta 1 | interleukin 12 receptor
Database Links Click here for help
Alphafold P42701 (Hs), Q60837 (Mm)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL4523226 (Hs)
Ensembl Gene ENSG00000096996 (Hs), ENSMUSG00000000791 (Mm), ENSRNOG00000019216 (Rn)
Entrez Gene 3594 (Hs), 16161 (Mm)
Human Protein Atlas ENSG00000096996 (Hs)
KEGG Gene hsa:3594 (Hs), mmu:16161 (Mm)
OMIM 601604 (Hs)
Pharos P42701 (Hs)
UniProtKB P42701 (Hs), Q60837 (Mm)
Wikipedia IL12RB1 (Hs)
Immunopharmacology Comments
This protein is a subunit of both the IL-12 and IL-23 cytokine receptors.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0071346 cellular response to type II interferon IDA
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 8 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051142 positive regulation of NK T cell proliferation IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 9 GO processes
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS
GO:0002827 positive regulation of T-helper 1 type immune response IDA
GO:0032819 positive regulation of natural killer cell proliferation IDA
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051142 positive regulation of NK T cell proliferation IDA
GO:2000318 positive regulation of T-helper 17 type immune response ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes
GO:0004896 cytokine receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0032729 positive regulation of type II interferon production IDA
GO:0032740 positive regulation of interleukin-17 production IC
GO:0071346 cellular response to type II interferon IDA
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GO:0035722 interleukin-12-mediated signaling pathway IEA
GO:0038155 interleukin-23-mediated signaling pathway IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 5 GO processes
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051142 positive regulation of NK T cell proliferation IDA
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0032819 positive regulation of natural killer cell proliferation IDA
GO:0042102 positive regulation of T cell proliferation IDA
GO:0042104 positive regulation of activated T cell proliferation IDA
GO:0043382 positive regulation of memory T cell differentiation ISS
GO:0051142 positive regulation of NK T cell proliferation IDA
GO:2000330 positive regulation of T-helper 17 cell lineage commitment ISS

How to cite this page

IL-12 receptor family: Interleukin-12 receptor, β1 subunit. Last modified on 22/03/2017. Accessed on 08/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1715.