IL-12   Click here for help

GtoPdb Ligand ID: 4977

Synonyms: IL-12 p70
Immunopharmacology Ligand
Comment: This is the signature member of the IL-12 family of cytokines. Structurally it is a heterodimer consisting of IL-12A (p35) and IL-12B (p40) subunits. An interchain disulphide bond between cysteine residue 74 in the IL-12A chain and 177 in the IL-12B chain link the heterodimer. IL-27 and IL-23 share homology with IL-12 at the subunit, receptor, and signalling levels, but each performs specific roles in the regulation of immune responses to infection, inflammation and also in the pathophysiology of autoimmune disorders [1].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Synonyms Click here for help
IL-12 p70
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IL12A interleukin 12A Human prepro-interleukin 12A CLMF, cytotoxic lymphocyte maturation factor 1, p35, IL-12A, IL-12, subunit p35, IL35 subunit, interleukin-12 alpha chain, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), interleukin 12, p35, natural killer cell stimulatory factor 1, 35 kD subunit, NF cell stimulatory factor chain 1, NFSK, NKSF1, p35
IL12B interleukin 12B Human prepro-interleukin 12B CLMF, CLMF2, cytotoxic lymphocyte maturation factor 2, p40, IL-12B, IL12, subunit p40, interleukin-12 beta chain, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin 12, p40, natural killer cell stimulatory factor-2, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2
Database Links Click here for help
Ensembl Gene ENSG00000168811 (Hs), ENSG00000113302 (Hs)
GtoPdb PubChem SID 178101675
Human Protein Atlas ENSG00000168811 (Hs), ENSG00000113302 (Hs)
Wikipedia Interleukin_12