IL-12 receptors are a subfamily of the IL-6 receptor family. IL12RB1 is shared between receptors for IL-12 and IL-23; the functional agonist at IL-12 receptors is a heterodimer of IL-12A/IL-12B, while that for IL-23 receptors is a heterodimer of IL-12B/IL-23A.

* Key recommended reading is highlighted with an asterisk

* Tait Wojno ED, Hunter CA, Stumhofer JS. (2019) The Immunobiology of the Interleukin-12 Family: Room for Discovery. Immunity, 50 (4): 851-870. DOI: 10.1016/j.immuni.2019.03.011 [PMID:30995503]

1. Fourie A, Cheng X, Chang L, Greving C, Patrick A, Knight B, Polidari D, Patch R, Bhandari A, Liu D. (2023) 1109 First-in-class oral peptide systemically targeting the IL-23 pathway. Journal of Investigative Dermatology, 143 (5 supplement): S190.

2. Lay CS, Bridges A, Goulding J, Briddon SJ, Soloviev Z, Craggs PD, Hill SJ. (2022) Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET. Cell Chem Biol, 29 (1): 19-29.e6. [PMID:34038748]