Top ▲

Interleukin 5 receptor, α subunit

Click here for help

Target id: 1706

Nomenclature: Interleukin 5 receptor, α subunit

Family: IL-3 receptor family

Quaternary Structure: Complexes
Interleukin-5 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 420 3p26.2 IL5RA interleukin 5 receptor subunit alpha
Mouse 1 415 6 49.19 cM Il5ra interleukin 5 receptor, alpha
Rat - - Il5ra interleukin 5 receptor subunit alpha
Previous and Unofficial Names Click here for help
CD125 | interleukin-5 receptor subunit alpha | interleukin 5 receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands Click here for help
IL-5 {Sp: Human}

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IL-5 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
benralizumab Peptide Approved drug Immunopharmacology Ligand Hs Binding 8.7 pKd 1
pKd 8.7 (Kd 2.13x10-9 M) [1]
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-5 receptor complex.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation


Show »

1. Koike M, Spitalny GL, Wheeler A, White B. (2013) Methods of reducing eosinophil levels. Patent number: US8501176. Assignee: Medimmune, Llc, Biowa, Inc.. Priority date: 14/05/2007. Publication date: 06/08/2013.

How to cite this page

IL-3 receptor family: Interleukin 5 receptor, α subunit. Last modified on 22/03/2017. Accessed on 16/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,