Quaternary Structure: Complexes

Interleukin-5 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	420	3p26.2	IL5RA	interleukin 5 receptor subunit alpha
Mouse	1	415	6 49.19 cM	Il5ra	interleukin 5 receptor, alpha
Rat	-	-		Il5ra	interleukin 5 receptor subunit alpha

Previous and Unofficial Names

CD125 | interleukin-5 receptor subunit alpha | interleukin 5 receptor

Database Links
Alphafold	Q01344 (Hs), P21183 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL3580483 (Hs), CHEMBL4523198 (Mm)
Ensembl Gene	ENSG00000091181 (Hs), ENSMUSG00000005364 (Mm), ENSRNOG00000005954 (Rn)
Entrez Gene	3568 (Hs), 16192 (Mm), 114103 (Rn)
Human Protein Atlas	ENSG00000091181 (Hs)
KEGG Gene	hsa:3568 (Hs), mmu:16192 (Mm), rno:114103 (Rn)
OMIM	147851 (Hs)
Pharos	Q01344 (Hs)
UniProtKB	Q01344 (Hs), P21183 (Mm)
Wikipedia	IL5RA (Hs)

Natural/Endogenous Ligands
IL-5 {Sp: Human}

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Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference IL-5 {Sp: Human} Hs Agonist - - ⤷

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference benralizumab Hs Binding 8.7 pKd 1 ⤷ pKd 8.7 (Kd 2.13x10-9 M) [1]

Immunopharmacology Comments

This is the ligand binding subunit of the functional IL-5 receptor complex.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Process:  Inflammation