IL-3 receptor family | Catalytic receptors | IUPHAR/BPS Guide to MALARIA PHARMACOLOGY

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IL-3 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-3 receptor family signal through a receptor complex comprising of a ligand-specific α subunit and a common β chain (CSF2RB, P32927), which is associated with Jak2 and signals primarily through Stat5.

Receptors

Complexes

Interleukin-3 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-5 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Granulocyte macrophage colony-stimulating factor receptor C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

Interleukin 3 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 5 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

GM-CSF receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Cytokine receptor common β subunit C Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Cohen ES, Minter RR, Harrison PR, Sleeman MA, Nash AD, Fabri LJ. (2012) Antibody molecule for human GM-CSF receptor alpha. Patent number: US8263075. Assignee: Medimmune Limited. Priority date: 27/03/2006. Publication date: 11/09/2012.

2. Koike M, Spitalny GL, Wheeler A, White B. (2013) Methods of reducing eosinophil levels. Patent number: US8501176. Assignee: Medimmune, Llc, Biowa, Inc.. Priority date: 14/05/2007. Publication date: 06/08/2013.

3. Morokata T, Ida K, Yamada T. (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol, 2 (12): 1693-702. [PMID:12469943]

How to cite this family page

Database page citation:

IL-3 receptor family. Accessed on 06/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=306.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Peach CJ, Gibb AJ, Kelly E, Mathie AA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors. Br J Pharmacol. 182: S259-S306.