benralizumab   Click here for help

GtoPdb Ligand ID: 7674

Synonyms: BIW-8405 | Fasenra® | KHK4563 | MEDI-563
Approved drug Immunopharmacology Ligand
benralizumab is an approved drug (FDA (2017), EMA (2018))
Compound class: Antibody
Comment: Benralizumab is a humanized, afucosylated mAb targeting the IL5Rα which is expressed by cells of the eosinophil lineage. The antibody is afucosylated (ie has fucose containing oligosaccharide side-chains removed) to improve structure, stability, and biological function.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB link.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: benralizumab

Classification Click here for help
Compound class Antibody
Approved drug? Yes. FDA (2017)  |  EMA (2018)
International Nonproprietary Names Click here for help
INN number INN
9233 benralizumab
Synonyms Click here for help
BIW-8405 | Fasenra® | KHK4563 | MEDI-563
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 334
Other databases
ChEMBL Ligand CHEMBL1742991
GtoPdb PubChem SID 223366009
Search PubMed clinical trials benralizumab
Search PubMed titles benralizumab
Search PubMed titles/abstracts benralizumab
Wikipedia Benralizumab