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Gene and Protein Information ![]() |
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Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 6 | 1 | 862 | 5q31.1 | TRPC7 | transient receptor potential cation channel subfamily C member 7 | 14 |
Mouse | 6 | 1 | 862 | 13 B1 | Trpc7 | transient receptor potential cation channel, subfamily C, member 7 | 10 |
Rat | 6 | 1 | 861 | 17p14 | Trpc7 | transient receptor potential cation channel, subfamily C, member 7 | 11 |
Previous and Unofficial Names ![]() |
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TRP7 [10,14] | capacitative calcium channel TRPC7 | short transient receptor potential channel 7 | transient receptor potential cation channel |
Database Links ![]() |
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Alphafold | Q9HCX4 (Hs), Q9WVC5 (Mm) |
CATH/Gene3D | 1.25.40.20 |
ChEMBL Target | CHEMBL4105799 (Hs), CHEMBL4523502 (Mm) |
Ensembl Gene | ENSG00000069018 (Hs), ENSMUSG00000021541 (Mm), ENSRNOG00000012727 (Rn) |
Entrez Gene | 57113 (Hs), 26946 (Mm), 282822 (Rn) |
Human Protein Atlas | ENSG00000069018 (Hs) |
KEGG Gene | hsa:57113 (Hs), mmu:26946 (Mm), rno:282822 (Rn) |
Pharos | Q9HCX4 (Hs) |
RefSeq Nucleotide | NM_020389 (Hs), NM_012035 (Mm), NM_001191691 (Rn) |
RefSeq Protein | NP_065122 (Hs), NP_036165 (Mm), NP_001178620 (Rn) |
UniProtKB | Q9HCX4 (Hs), Q9WVC5 (Mm) |
Wikipedia | TRPC7 (Hs) |
Associated Proteins ![]() |
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Ion Selectivity and Conductance ![]() |
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Chemical activators (Human) |
diacylglycerols |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific activator tables |
Channel Blockers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific channel blocker tables |
Immunopharmacology Comments |
Expressed on chicken B cells [12]. |
Tissue Distribution ![]() |
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Functional Assays ![]() |
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Physiological Functions ![]() |
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1. Dietrich A, Kalwa H, Rost BR, Gudermann T. (2005) The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch, 451 (1): 72-80. [PMID:15971081]
2. Facemire CS, Mohler PJ, Arendshorst WJ. (2004) Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation. Am J Physiol Renal Physiol, 286 (3): F546-51. [PMID:14678949]
3. Häfner S, Burg F, Kannler M, Urban N, Mayer P, Dietrich A, Trauner D, Broichhagen J, Schaefer M. (2018) A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6. ChemMedChem, 13 (10): 1028-1035. [PMID:29522264]
4. Jang Y, Lee Y, Kim SM, Yang YD, Jung J, Oh U. (2012) Quantitative analysis of TRP channel genes in mouse organs. Arch Pharm Res, 35 (10): 1823-30. [PMID:23139135]
5. Lievremont JP, Numaga T, Vazquez G, Lemonnier L, Hara Y, Mori E, Trebak M, Moss SE, Bird GS, Mori Y et al.. (2005) The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. J Biol Chem, 280 (42): 35346-51. [PMID:16123040]
6. Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT et al.. (2019) In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A, 116 (20): 10156-10161. [PMID:31028142]
7. Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G. (2005) MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem, 280 (19): 19393-400. [PMID:15757897]
8. Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N, Linz W, Schmidt T, Löhn M et al.. (2015) Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol, 172 (14): 3650-60. [PMID:25847402]
9. Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T et al.. (2009) A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. J Biol Chem, 284 (49): 34400-12. [PMID:19812035]
10. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K et al.. (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem, 274 (39): 27359-70. [PMID:10488066]
11. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, Mori Y, Nagao T, Kurose H. (2006) TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J, 25 (22): 5305-16. [PMID:17082763]
12. Parenti A, De Logu F, Geppetti P, Benemei S. (2016) What is the evidence for the role of TRP channels in inflammatory and immune cells?. Br J Pharmacol, 173 (6): 953-69. [PMID:26603538]
13. Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller M, Tian J, Zhu J, Xu J, Wen M et al.. (2017) Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem, 60 (11): 4680-4692. [PMID:28395140]
14. Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN. (2002) Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem, 277 (14): 12302-9. [PMID:11805119]
15. Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN. (2002) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res, 109 (1-2): 95-104. [PMID:12531519]
16. Satoh S, Tanaka H, Ueda Y, Oyama J, Sugano M, Sumimoto H, Mori Y, Makino N. (2007) Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis. Mol Cell Biochem, 294 (1-2): 205-15. [PMID:16838106]
17. Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R. (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (Lond.), 561 (Pt 2): 415-32. [PMID:15579537]
18. Sinkins WG, Goel M, Estacion M, Schilling WP. (2004) Association of immunophilins with mammalian TRPC channels. J Biol Chem, 279 (33): 34521-9. [PMID:15199065]
19. Takumida M, Anniko M. (2009) Expression of canonical transient receptor potential channel (TRPC) 1-7 in the mouse inner ear. Acta Otolaryngol, 129 (12): 1351-8. [PMID:19922081]
20. Tiapko O, Shrestha N, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier WF, Kubista H, Freichel M et al.. (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem Sci, 10 (9): 2837-2842. [PMID:30997005]
21. Urban N, Wang L, Kwiek S, Rademann J, Kuebler WM, Schaefer M. (2016) Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Mol Pharmacol, 89 (1): 197-213. [PMID:26500253]
22. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P et al.. (2011) Melanopsin signalling in mammalian iris and retina. Nature, 479 (7371): 67-73. [PMID:22051675]
23. Zagranichnaya TK, Wu X, Villereal ML. (2005) Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem, 280 (33): 29559-69. [PMID:15972814]
Blair NT, Caceres AI, Carvacho I, Chaudhuri D, Clapham DE, De Clercq K, Delling M, Doerner JF, Fan L, Grimm CM, Ha K, Hu M, Jabba SV, Jordt SE, Julius D, Kahle KT, Liu Q, Liu B, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz SC, Tian J, Tong D, Vriens J, Wu LJ, Xu H, Yang F, Yang W, Yue L, Zhu MX. Transient Receptor Potential channels (TRP) in GtoPdb v.2025.1. IUPHAR/BPS Guide to Pharmacology CITE. 2025; 2025(1). Available from: https://doi.org/10.2218/gtopdb/F78/2025.1.