IL-36α   Click here for help

GtoPdb Ligand ID: 5881

Synonyms: FIL1 epsilon | interleukin-1 epsilon (IL-1 epsilon)
Immunopharmacology Ligand
Comment: IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist form the IL-36 group of cytokines and are a subset of the IL-1 cytokine family. IL-36α, IL-36β, IL-36γ are agonists of the IL-36 receptor complex (IL1RL2/IL1R-rp2/IL-36 receptor) and activate NF-κB and MAP kinase pathways inducing a pro-inflammatory response. The IL-36 receptor antagonist as its name suggests antagonises signalling by the IL-36 receptor agonists to reduce their pro-inflammatory function.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Synonyms Click here for help
FIL1 epsilon | interleukin-1 epsilon (IL-1 epsilon)
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IL36A interleukin 36 alpha Human interleukin-36 alpha FIL1, FIL1E, IL1(EPSILON), IL-1F6, IL1F6, interleukin 1 family, member 6 (epsilon), interleukin 36, alpha, MGC129552, MGC129553
Database Links Click here for help
Ensembl Gene ENSG00000136694 (Hs)
GtoPdb PubChem SID 178102505
Human Protein Atlas ENSG00000136694 (Hs)
UniProtKB Q9UHA7 (Hs)
Wikipedia IL36A