IL-36α   Click here for help

GtoPdb Ligand ID: 5881

Synonyms: FIL1 epsilon | interleukin-1 epsilon (IL-1 epsilon)
Immunopharmacology Ligand
Comment: IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist form the IL-36 group of cytokines and are a subset of the IL-1 cytokine family. IL-36α, IL-36β, IL-36γ are agonists of the IL-36 receptor complex (IL1RL2/IL1R-rp2/IL-36 receptor) and activate NF-κB and MAP kinase pathways inducing a pro-inflammatory response. The IL-36 receptor antagonist as its name suggests antagonises signalling by the IL-36 receptor agonists to reduce their pro-inflammatory function.
Species: Human
1. Gresnigt MS, van de Veerdonk FL. (2013)
Biology of IL-36 cytokines and their role in disease.
Semin Immunol, 25 (6): 458-65. [PMID:24355486]