IL-18   Click here for help

GtoPdb Ligand ID: 4983

Synonyms: ibocatdekin | interferon-γ-inducing factor | interleukin-1 gamma (IL-1 gamma) | interleukin-18
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-18 is an IL-1 family cytokine. It acts as a pleiotropic pro-inflammatory cytokine, and it is important for host innate and adaptive immune defense against pathogenic infections. Dysregulated IL-18 activity is associated with inflammatory and autoimmune diseases (e.g. rheumatoid arthritis, Crohn's disease, MS and lupus), allergies, and neurological disorders. IL-18 and its signalling partners are protein targets for anti-inflammatory drug development.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Synonyms Click here for help
ibocatdekin | interferon-γ-inducing factor | interleukin-1 gamma (IL-1 gamma) | interleukin-18
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IL18 interleukin 18 Human prepro-interleukin-18 IGIF, IL-18, IL1F4, IL-1g, interleukin 18 (interferon-gamma-inducing factor)
Database Links Click here for help
Ensembl Gene ENSG00000150782 (Hs)
GtoPdb PubChem SID 178101680
Human Protein Atlas ENSG00000150782 (Hs)
UniProtKB Q14116 (Hs)
Wikipedia Interleukin_18