Synonyms: compound 43d [PMID: 31721572] | SAR-439859 | SAR439859
Compound class:
Synthetic organic
Comment: Amcenestrant (SAR439859) is a selective estrogen receptor degrader (SERD) [1]. It was designed (by Sanofi) to have improved pharmacokinetic properties compared to the existing clinically used SERD, fulvestrant. An X-ray structure of SAR439859 in complex with the ERα ligand binding domain indicates that the ligand occupies the orthosteric estradiol binding cavity.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
6-(2,4-dichlorophenyl)-5-[4-[1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid |
International Nonproprietary Names | |
INN number | INN |
11312 | amcenestrant |
Synonyms |
compound 43d [PMID: 31721572] | SAR-439859 | SAR439859 |
Database Links | |
GtoPdb PubChem SID | 404859013 |
PubChem CID | 137449472 |
RCSB PDB Ligand | L5B |
Search Google for chemical match using the InChIKey | KISZAGQTIXIVAR-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | KISZAGQTIXIVAR |
Search PubMed clinical trials | amcenestrant |
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Search PubMed titles/abstracts | amcenestrant |
UniChem Compound Search for chemical match using the InChIKey | KISZAGQTIXIVAR-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KISZAGQTIXIVAR-UHFFFAOYSA-N |