Synonyms: compound 43d [PMID: 31721572] | SAR-439859 | SAR439859
Compound class:
Synthetic organic
Comment: Amcenestrant (SAR439859) is a selective estrogen receptor degrader (SERD) [1]. It was designed (by Sanofi) to have improved pharmacokinetic properties compared to the existing clinically used SERD, fulvestrant. An X-ray structure of SAR439859 in complex with the ERα ligand binding domain indicates that the ligand occupies the orthosteric estradiol binding cavity.
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No information available. |
Summary of Clinical Use |
SAR439859 has been advanced to Phase 2 clinical evaluation in patients with advanced or metastatic ER+ve breast cancer. Click here to link to ClinicalTrials.gov's full list of SAR439859 studies. |