CZC 24832   Click here for help

GtoPdb Ligand ID: 6653

Synonyms: CZC-24832 | CZC24832
Compound class: Synthetic organic
Comment: CZC24832 is the first reported selective PI3Kγ inhibitor [1]. The activity of CZC24832 has been investigated in preclinical studies.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 123.65
Molecular weight 364.11
XLogP 1.39
No. Lipinski's rules broken 0
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Canonical SMILES Nc1nn2c(n1)c(F)cc(c2)c1cncc(c1)S(=O)(=O)NC(C)(C)C
Isomeric SMILES Nc1nn2c(n1)c(F)cc(c2)c1cncc(c1)S(=O)(=O)NC(C)(C)C
InChI InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-9(6-18-7-11)10-5-12(16)13-19-14(17)20-22(13)8-10/h4-8,21H,1-3H3,(H2,17,20)
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Molecular structure representations generated using Open Babel