ChEMBL ligand: CHEMBL2064571
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of PI3Kalpha by high throughput chemoproteomics binding assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kalpha assessed as change in pIC50 by kinobeads assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL	Inhibition of PI3Kbeta by high throughput chemoproteomics binding assay	B	5.9	pIC50	1258.93	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kbeta assessed as change in pIC50 by kinobeads assay	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL	Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay	B	5.1	pIC50	7943.28	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kdelta assessed as change in pIC50 by kinobeads assay	B	5.1	pIC50	7943.28	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb	-	-	7.7	pKd	-	-	-	Nat Chem Biol (2012) 8: 576-82 [PMID:22544264]
GtoPdb	-	-	7.57	pIC50	27	nM	IC50	Nat Chem Biol (2012) 8: 576-82 [PMID:22544264]
ChEMBL	Inhibition of PI3Kgamma by high throughput chemoproteomics binding assay	B	7.6	pIC50	25.12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kgamma by kinobeads assay	B	7.6	pIC50	25.12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]