ChEMBL ligand: CHEMBL2064571
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of PI3Kalpha by high throughput chemoproteomics binding assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kalpha assessed as change in pIC50 by kinobeads assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL	Inhibition of PI3Kbeta by high throughput chemoproteomics binding assay	B	5.9	pIC50	1258.93	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kbeta assessed as change in pIC50 by kinobeads assay	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL	Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay	B	5.1	pIC50	7943.28	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kdelta assessed as change in pIC50 by kinobeads assay	B	5.1	pIC50	7943.28	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb	-	-	7.7	pKd	-	-	-	Nat Chem Biol (2012) 8: 576-82 [PMID:22544264]
GtoPdb	-	-	7.57	pIC50	27	nM	IC50	Nat Chem Biol (2012) 8: 576-82 [PMID:22544264]
ChEMBL	Inhibition of PI3Kgamma by high throughput chemoproteomics binding assay	B	7.6	pIC50	25.12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5257-5263 [PMID:22819766]
ChEMBL	Inhibition of PI3Kgamma by kinobeads assay	B	7.6	pIC50	25.12	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4613-4618 [PMID:22726925]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]