tamatinib   Click here for help

GtoPdb Ligand ID: 5706

Synonyms: R 406 | R-406 | R406 free base
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Tamatinib (R406) is a potent ATP-competitive (Type I) Syk inhibitor. It is the active form of the prodrug fostamatinib.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 128.75
Molecular weight 470.17
XLogP 2.72
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES COc1cc(Nc2ncc(c(n2)Nc2ccc3c(n2)NC(=O)C(O3)(C)C)F)cc(c1OC)OC
Isomeric SMILES COc1cc(Nc2ncc(c(n2)Nc2ccc3c(n2)NC(=O)C(O3)(C)C)F)cc(c1OC)OC
InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
InChI Key NHHQJBCNYHBUSI-UHFFFAOYSA-N

Large-scale screening data

DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 3,5

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
fms related receptor tyrosine kinase 3 FLT3(D835Y) Hs Inhibitor Inhibition 9.4 pKd
fms related receptor tyrosine kinase 3 FLT3(ITD) Hs Inhibitor Inhibition 9.3 pKd
fms related receptor tyrosine kinase 3 FLT3(D835H) Hs Inhibitor Inhibition 9.2 pKd
fms related receptor tyrosine kinase 3 FLT3(K663Q) Hs Inhibitor Inhibition 9.2 pKd
fms related receptor tyrosine kinase 3 FLT3 Hs Inhibitor Inhibition 9.1 pKd
fms related receptor tyrosine kinase 3 FLT3(N841I) Hs Inhibitor Inhibition 8.8 pKd
serine/threonine kinase 16 STK16 Hs Inhibitor Inhibition 8.8 pKd
ret proto-oncogene RET(V804L) Hs Inhibitor Inhibition 8.7 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(D816V) Hs Inhibitor Inhibition 8.6 pKd
ret proto-oncogene RET(V804M) Hs Inhibitor Inhibition 8.5 pKd
Displaying the top 10 targets  View all targets in screen »