valbenazine   Click here for help

GtoPdb Ligand ID: 8694

Synonyms: Ingrezza® | NBI 98854 | NBI-98854
Approved drug
valbenazine is an approved drug (FDA (2017))
Compound class: Synthetic organic
Comment: Valbenazine is an analogue of tetrabenazine, which similarly selectively inhibits the monoamine transporter SLC18A2 (VMAT2). A search of patent literature reveals valbenazine as example 2-1 in US8357697 B2 [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 74.02
Molecular weight 418.28
XLogP 3.88
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc2c(cc1OC)CCN1C2CC(OC(=O)C(C(C)C)N)C(C1)CC(C)C
Isomeric SMILES COc1cc2c(cc1OC)CCN1[C@@H]2C[C@@H](OC(=O)[C@H](C(C)C)N)[C@@H](C1)CC(C)C
InChI InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1
1. Gano KW. (2013)
Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol compounds and methods relating thereto.
Patent number: US8357697 B2. Assignee: Neurocrine Biosciences, Inc.. Priority date: 08/11/2006. Publication date: 22/01/2013.
2. Kim ES. (2017)
Valbenazine: First Global Approval.
Drugs, 77 (10): 1123-1129. [PMID:28578484]