valbenazine [Ligand Id: 8694] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2364639 (Mt-5199, NBI-98854, Valbenazine)
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  • Vesicular monoamine transporter 2 in Rat [GtoPdb: 1012] [UniProtKB: Q01827]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 5.77 pIC50 1700 nM IC50 Eur J Med Chem (2021) 224: 113718-113718 [PMID:34329999]
Vesicular monoamine transporter 2 in Rat [GtoPdb: 1012] [UniProtKB: Q01827]
GtoPdb Displacement binding assay using rat brain homogenate. - 6.73 pKi 187 nM Ki US8357697 B2. Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol compounds and methods relating thereto. (2013)

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]