Ligand id: 864

Name: CCK-8

Species: Human, Mouse, Rat

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View more information in the IUPHAR Pharmacology Education Project: cholecystokinin, cck-8

Structure and Physico-chemical Properties

2D Structure
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1. Goto Y, Hattori A, Ishii Y, Mizutani S, Tsujimoto M. (2006)
Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV.
J. Biol. Chem., 281 (33): 23503-13. [PMID:16790432]
2. Hughes J, Boden P, Costall B, Domeney A, Kelly E, Horwell DC, Hunter JC, Pinnock RD, Woodruff GN. (1990)
Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
Proc. Natl. Acad. Sci. U.S.A., 87 (17): 6728-32. [PMID:1975695]
3. Ito M, Matsui T, Taniguchi T, Tsukamoto T, Murayama T, Arima N, Nakata H, Chiba T, Chihara K. (1993)
Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin.
J. Biol. Chem., 268 (24): 18300-5. [PMID:8349705]
4. Lee YM, Beinborn M, McBride EW, Lu M, Kolakowski Jr LF, Kopin AS. (1993)
The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.
J. Biol. Chem., 268 (11): 8164-9. [PMID:7681836]
5. Migaud M, Durieux C, Viereck J, Soroca-Lucas E, FourniĆ©-Zaluski MC, Roques BP. (1996)
The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A.
Peptides, 17 (4): 601-7. [PMID:8804068]
6. Zini S, Fournie-Zaluski MC, Chauvel E, Roques BP, Corvol P, Llorens-Cortes C. (1996)
Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.
Proc. Natl. Acad. Sci. U.S.A., 93 (21): 11968-73. [PMID:8876246]