- Guide to PHARMACOLOGY
Synonyms: BCX-1777 | BCX1777 | Fodosine® (proposed trade name) | immucillin H | immucillin-H
Compound class: Synthetic organic
Comment: Forodesine is a picomolar inhibitor of purine nucleoside phosphorylase (PNP) [1,4].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Kicska GA, Long L, Hörig H, Fairchild C, Tyler PC, Furneaux RH, Schramm VL, Kaufman HL. (2001)
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.
Proc. Natl. Acad. Sci. U.S.A., 98 (8): 4593-8. [PMID:11287638]
2. Kicska GA, Tyler PC, Evans GB, Furneaux RH, Kim K, Schramm VL. (2002)
Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum.
J. Biol. Chem., 277 (5): 3219-25. [PMID:11707439]
3. Kicska GA, Tyler PC, Evans GB, Furneaux RH, Schramm VL, Kim K. (2002)
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.
J. Biol. Chem., 277 (5): 3226-31. [PMID:11706018]
4. Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL. (1998)
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.
Biochemistry, 37 (24): 8615-21. [PMID:9628722]