- Guide to PHARMACOLOGY
Synonyms: Addyi® | BIMT-17 | Girosa® (proposed trade name)
flibanserin is an approved drug (FDA (2015))
Compound class: Synthetic organic
Comment: Flibanserin is reported as a serotonin 5-HT1A agonist and 5-HT2A antagonist . The compound was originally investigated as a antidepressant [3-4].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Allers KA, Dremencov E, Ceci A, Flik G, Ferger B, Cremers TI, Ittrich C, Sommer B. (2010)
Acute and repeated flibanserin administration in female rats modulates monoamines differentially across brain areas: a microdialysis study.
J Sex Med, 7 (5): 1757-67. [PMID:20163532]
2. Borsini F, Evans K, Jason K, Rohde F, Alexander B, Pollentier S. (2002)
Pharmacology of flibanserin.
CNS Drug Rev, 8 (2): 117-42. [PMID:12177684]
3. D'Aquila P, Monleon S, Borsini F, Brain P, Willner P. (1997)
Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant.
Eur J Pharmacol, 340 (2-3): 121-32. [PMID:9537806]
4. Invernizzi RW, Sacchetti G, Parini S, Acconcia S, Samanin R. (2003)
Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.
Br J Pharmacol, 139 (7): 1281-8. [PMID:12890707]