flibanserin [Ligand Id: 8182] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL231068 (Addyi, BIMT 17, BIMT-17, BIMT 17 BS, BIMT-17-BS, Ectris, Flibanserin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Displacement of [3H]-5-OH-DPAT from human 5-HT1AR in human brain tissue by radioligand binding assay | B | 7.93 | pKi | 11.8 | nM | Ki | Eur J Med Chem (2022) 235: 114319-114319 [PMID:35367707] |
| GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | CNS Drug Rev (2002) 8: 117-42 [PMID:12177684] |
| ChEMBL | Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding | F | 6.2 | pEC50 | 630.96 | nM | EC50 | J Med Chem (2007) 50: 5024-5033 [PMID:17803293] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Binding affinity to 5HT1A receptor in rat cortex membrane | B | 7.93 | pKi | 11.75 | nM | Ki | J Med Chem (2007) 50: 5024-5033 [PMID:17803293] |
| 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 7.31 | pKi | 49 | nM | Ki | CNS Drug Rev (2002) 8: 117-42 [PMID:12177684] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
