CCL2   Click here for help

GtoPdb Ligand ID: 771

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
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An overview of glutaminyl cyclase inhibitors for Alzheimer's disease.
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Therapeutic potential of glutaminyl cyclases: Current status and emerging trends.
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Glycosylation enhances functional stability of the chemotactic cytokine CCL2.
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Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Eur J Med Chem, 226: 113819. [PMID:34536669]
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