CCL2   Click here for help

GtoPdb Ligand ID: 771

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN. (1997)
Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.
Eur J Biochem, 248 (2): 507-15. [PMID:9346309]
2. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS. (1996)
Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
J Exp Med, 183 (5): 2349-54. [PMID:8642344]
3. Kaminsky DE, Rogers TJ. (2008)
Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes.
J Neuroimmune Pharmacol, 3 (2): 75-82. [PMID:18247127]
4. Lüttichau HR, Clark-Lewis I, Jensen PØ, Moser C, Gerstoft J, Schwartz TW. (2003)
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
J Biol Chem, 278 (13): 10928-33. [PMID:12554737]
5. Mirzadegan T, Diehl F, Ebi B, Bhakta S, Polsky I, McCarley D, Mulkins M, Weatherhead GS, Lapierre JM, Dankwardt J et al.. (2000)
Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle.
J Biol Chem, 275 (33): 25562-71. [PMID:10770925]
6. Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, Holbrook M. (2005)
Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.
Biochem Pharmacol, 71 (1-2): 163-72. [PMID:16298345]
7. Parody TR, Stone MJ. (2004)
High level expression, activation, and antagonism of CC chemokine receptors CCR2 and CCR3 in Chinese hamster ovary cells.
Cytokine, 27 (1): 38-46. [PMID:15207250]
8. Ruggiero P, Flati S, Di Cioccio V, Maurizi G, Macchia G, Facchin A, Anacardio R, Maras A, Lucarelli M, Boraschi D. (2003)
Glycosylation enhances functional stability of the chemotactic cytokine CCL2.
Eur Cytokine Netw, 14 (2): 91-6. [PMID:12957789]
9. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA. (1997)
High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
J Clin Invest, 100 (5): 1137-43. [PMID:9276730]