CCL2   Click here for help

GtoPdb Ligand ID: 771

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. It is cleaved and activated by MMP12. CCL2 attracts monocytes, memory T cells and dendritic cells to inflammatory sites.
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriasis Disease Ontology: DOID:8893
 CCL2 is implicated in the pathogenesis of psoriasis.
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
 CCL2 is implicated in the pathogenesis of RA.
Immunopaedia Case Studies Links
A case of cough, wasting and lymphadenopathy