- Guide to PHARMACOLOGY
Synonyms: DU-176 | DU-176b | edoxaban tosylate | Lixiana® | Savaysa®
edoxaban is an approved drug (EMA & FDA (2015))
Compound class: Synthetic organic
Comment: Edoxaban is an oral, once-daily factor Xa inhibitor anticoagulant.
Marketed formulations contain edoxaban tosylate (PubChem CID 44610678).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: edoxaban
1. Furugohri T, Isobe K, Honda Y, Kamisato-Matsumoto C, Sugiyama N, Nagahara T, Morishima Y, Shibano T. (2008)
DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles.
J Thromb Haemost, 6 (9): 1542-9. [PMID:18624979]
2. Pinto DJ, Smallheer JM, Cheney DL, Knabb RM, Wexler RR. (2010)
Factor Xa inhibitors: next-generation antithrombotic agents.
J Med Chem, 53 (17): 6243-74. [PMID:20503967]