- Guide to PHARMACOLOGY
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-27 is an IL-12 family cytokine. It is a heterodimeric cytokine that contains an α and a β subunit and is expressed by activated antigen presenting cells . IL-27 interaction with its receptor complex activates the JAK/STAT and p38 MAPK pathways.
1. Meka RR, Venkatesha SH, Dudics S, Acharya B, Moudgil KD. (2015)
IL-27-induced modulation of autoimmunity and its therapeutic potential.
Autoimmun Rev, 14 (12): 1131-41. [PMID:26253381]
2. Yoshida H, Hunter CA. (2015)
The immunobiology of interleukin-27.
Annu Rev Immunol, 33: 417-43. [PMID:25861977]