PF750   Click here for help

GtoPdb Ligand ID: 5244

Synonyms: PF 750 | PF-750
Compound class: Synthetic organic
Comment: PF750 is an inhibitor of fatty acid amide hydrolase (FAAH) [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 45.23
Molecular weight 345.18
XLogP 3.77
No. Lipinski's rules broken 0
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Canonical SMILES O=C(N1CCC(CC1)Cc1cnc2c(c1)cccc2)Nc1ccccc1
Isomeric SMILES O=C(N1CCC(CC1)Cc1cnc2c(c1)cccc2)Nc1ccccc1
InChI InChI=1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26)
1. Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP et al.. (2007)
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.
Biochemistry, 46 (45): 13019-30. [PMID:17949010]
2. Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. (2018)
Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors.
ACS Omega, 3 (10): 14076-14086. DOI: 10.1021/acsomega.8b01625 [PMID:30411058]
3. Wei BQ, Mikkelsen TS, McKinney MK, Lander ES, Cravatt BF. (2006)
A second fatty acid amide hydrolase with variable distribution among placental mammals.
J Biol Chem, 281 (48): 36569-78. [PMID:17015445]