ChEMBL ligand: CHEMBL560590 (PF-750)
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] There should be some charts here, you may need to enable JavaScript!
epoxide hydrolase 2 in Human [GtoPdb: 2970] [UniProtKB: P34913] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL	Irreversible inhibition of human recombinant FAAH using N-arachidonyl-7-amino-4-methylcoumarin as substrate preincubated for 20 mins before substrate addition by fluorescence assay	B	5.96	pIC50	1090	nM	IC50	Bioorg Med Chem (2013) 21: 5188-5197 [PMID:23891163]
ChEMBL	Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21-AI preincubated for 5 mins followed by olamide substrate addition measured every 10 sec intervals for 30 mins by spectrophotometry	B	6.23	pIC50	595	nM	IC50	J Med Chem (2017) 60: 4-46 [PMID:27766867]
ChEMBL	Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting	B	7.48	pIC50	33	nM	IC50	J Med Chem (2011) 54: 6812-6823 [PMID:21899370]
ChEMBL	Inhibition of FAAH	B	7.79	pIC50	16.2	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4241-4244 [PMID:19515560]
ChEMBL	Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21 preincubated for 60 mins followed by olamide substrate addition measured every 10 sec intervals for 30 mins by spectrophotometry	B	7.79	pIC50	16.2	nM	IC50	J Med Chem (2017) 60: 4-46 [PMID:27766867]
ChEMBL	Inhibition of FAAH (unknown origin)	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem (2013) 21: 28-41 [PMID:23218778]
GtoPdb	-	-	7.8	pIC50	15.8	nM	IC50	Biochemistry (2007) 46: 13019-30 [PMID:17949010]
GtoPdb	Following a 5 min preincubation with inhibitor.	-	8.19	pIC50	6.4	nM	IC50	ACS Omega (2018) 3: 14076-14086 [PMID:30411058]
ChEMBL	Inhibition of human FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay	B	8.34	pIC50	4.6	nM	IC50	Medchemcomm (2012) 3: 611-619
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL	Inhibition of rat FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay	B	7.77	pIC50	17	nM	IC50	Medchemcomm (2012) 3: 611-619
epoxide hydrolase 2 in Human [GtoPdb: 2970] [UniProtKB: P34913]
GtoPdb	-	-	6.19	pIC50	640	nM	IC50	ACS Omega (2018) 3: 14076-14086 [PMID:30411058]
GtoPdb	Following a 5 min preincubation with inhibitor.	-	6.44	pIC50	360	nM	IC50	ACS Omega (2018) 3: 14076-14086 [PMID:30411058]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]