- Guide to PHARMACOLOGY
Synonyms: Herpesvirus entry mediator-ligand | TR2
Compound class: Endogenous peptide in human, mouse or rat
Comment: LIGHT is a tumour necrosis factor superfamily protein that regulates T-cell-based inflammatory reactions, especially in mucosal membranes [1-2]. It exists as a membrane-anchored protein and as a soluble form in the serum. LIGHT's biological activity is mediated via binding to TNF superfamily receptors: lymphotoxin β receptor (LTβR; TNFRSF3), herpes virus entry mediator (HVEM; TNFRSF14), and decoy receptor 3 (DcR3; TNFRSF6B).
1. Cohavy O, Zhou J, Ware CF, Targan SR. (2005)
LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.
J Immunol, 174 (2): 646-53. [PMID:15634882]
2. Ware CF. (2005)
Network communications: lymphotoxins, LIGHT, and TNF.
Annu Rev Immunol, 23: 787-819. [PMID:15771586]
3. Zhang M, Perrin L, Pardo P. (2017)
A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti-LIGHT Antibody, SAR252067.
Clin Pharmacol Drug Dev, 6 (3): 292-301. [PMID:27545119]