LIGHT

Home
Ligands
LIGHT (Human)

GtoPdb Ligand ID: 5070

Synonyms: Herpesvirus entry mediator-ligand | TR2

Compound class: Endogenous peptide in human, mouse or rat

Comment: LIGHT is a tumour necrosis factor superfamily protein that regulates T-cell-based inflammatory reactions, especially in mucosal membranes [1-2]. It exists as a membrane-anchored protein and as a soluble form in the serum. LIGHT's biological activity is mediated via binding to TNF superfamily receptors: lymphotoxin β receptor (LTβR; TNFRSF3), herpes virus entry mediator (HVEM; TNFRSF14), and decoy receptor 3 (DcR3; TNFRSF6B).

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
LIGHT protein is a ligand for TNFRSF14 (herpesvirus entry mediator ligand, HVEML). It appears to function as a costimulatory mediator for lymphoid cell activation and proliferation, and as a barrier to herpesvirus infection.

Immunopharmacology Comments

LIGHT protein is a ligand for TNFRSF14 (herpesvirus entry mediator ligand, HVEML). It appears to function as a costimulatory mediator for lymphoid cell activation and proliferation, and as a barrier to herpesvirus infection.