IL-12

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Ligands
IL-12 (Human)

GtoPdb Ligand ID: 4977

Synonyms: IL-12 p70

Compound class: Endogenous peptide in human, mouse or rat

Comment: This is the signature member of the IL-12 family of cytokines. Structurally it is a heterodimer consisting of IL-12A (p35) and IL-12B (p40) subunits. An interchain disulphide bond between cysteine residue 74 in the IL-12A chain and 177 in the IL-12B chain link the heterodimer. IL-27 and IL-23 share homology with IL-12 at the subunit, receptor, and signalling levels, but each performs specific roles in the regulation of immune responses to infection, inflammation and also in the pathophysiology of autoimmune disorders [1].

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

References
1. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. (2009) The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets, 8 (1): 40-52. [PMID:19275692]

References

1. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. (2009)
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders.
Inflamm Allergy Drug Targets, 8 (1): 40-52. [PMID:19275692]