IL-1β

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Ligands
IL-1β (Human)

GtoPdb Ligand ID: 4974

Synonyms: catabolin | interleukin-1 beta

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-1β is an IL-1 family cytokine produced from the IL1B gene. It is produced by activated macrophages as a proprotein which is cleaved by cytosolic caspase 1 to the mature, active molecule.

Species: Human

References
1. Gram H, Di Padova FE. (2008) Antibodies to human IL-1β. Patent number: US7446175. Assignee: Novartis Ag. Priority date: 22/08/2000. Publication date: 04/11/2008.
2. Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N et al.. (2008) Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum, 58 (8): 2443-52. [PMID:18668535]
3. Issafras H, Corbin JA, Goldfine ID, Roell MK. (2014) Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther, 348 (1): 202-15. [PMID:24194526]
4. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015) Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs, 7 (3): 605-19. [PMID:25764208]
5. Mantovani A, Dinarello CA, Molgora M, Garlanda C. (2019) Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity, 50 (4): 778-795. DOI: 10.1016/j.immuni.2019.03.012 [PMID:30995499]
6. Masat L, Haak-Frendscho M, Chen G, Horwitz A, Roell M. (2009) IL-1β binding antibodies and fragments thereof. Patent number: US7531166. Assignee: Xoma Technology, Ltd. Priority date: 27/02/2015. Publication date: 12/03/2010.
7. McDermott MF. (2009) Rilonacept in the treatment of chronic inflammatory disorders. Drugs Today, 45 (6): 423-30. [PMID:19649332]
8. Schett G, Dayer JM, Manger B. (2016) Interleukin-1 function and role in rheumatic disease. Nat Rev Rheumatol, 12 (1): 14-24. [PMID:26656658]
9. Williams JW, Huang LH, Randolph GJ. (2019) Cytokine Circuits in Cardiovascular Disease. Immunity, 50 (4): 941-954. [PMID:30995508]

References

1. Gram H, Di Padova FE. (2008)
Antibodies to human IL-1β.
Patent number: US7446175. Assignee: Novartis Ag. Priority date: 22/08/2000. Publication date: 04/11/2008.

2. Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N et al.. (2008)
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.
Arthritis Rheum, 58 (8): 2443-52. [PMID:18668535]

3. Issafras H, Corbin JA, Goldfine ID, Roell MK. (2014)
Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties.
J Pharmacol Exp Ther, 348 (1): 202-15. [PMID:24194526]

4. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015)
Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.
MAbs, 7 (3): 605-19. [PMID:25764208]

5. Mantovani A, Dinarello CA, Molgora M, Garlanda C. (2019)
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity.
Immunity, 50 (4): 778-795. DOI: 10.1016/j.immuni.2019.03.012 [PMID:30995499]

6. Masat L, Haak-Frendscho M, Chen G, Horwitz A, Roell M. (2009)
IL-1β binding antibodies and fragments thereof.
Patent number: US7531166. Assignee: Xoma Technology, Ltd. Priority date: 27/02/2015. Publication date: 12/03/2010.

7. McDermott MF. (2009)
Rilonacept in the treatment of chronic inflammatory disorders.
Drugs Today, 45 (6): 423-30. [PMID:19649332]

8. Schett G, Dayer JM, Manger B. (2016)
Interleukin-1 function and role in rheumatic disease.
Nat Rev Rheumatol, 12 (1): 14-24. [PMID:26656658]

9. Williams JW, Huang LH, Randolph GJ. (2019)
Cytokine Circuits in Cardiovascular Disease.
Immunity, 50 (4): 941-954. [PMID:30995508]