IL-1β

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Ligands
IL-1β (Human)

GtoPdb Ligand ID: 4974

Synonyms: catabolin | interleukin-1 beta

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-1β is an IL-1 family cytokine produced from the IL1B gene. It is produced by activated macrophages as a proprotein which is cleaved by cytosolic caspase 1 to the mature, active molecule.

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
IL-1β is a very important mediator of the inflammatory response [5]. Increased production of IL-1β underlies the pathology of a number of different autoinflammatory syndromes [8] and inflammatory mechanisms that drive atherosclerosis and cardiovascular disease [9], so it is the target of drug development efforts. Anti-IL-1β drugs already approved include rilonacept and canakinumab.

Immunopharmacology Comments

IL-1β is a very important mediator of the inflammatory response [5]. Increased production of IL-1β underlies the pathology of a number of different autoinflammatory syndromes [8] and inflammatory mechanisms that drive atherosclerosis and cardiovascular disease [9], so it is the target of drug development efforts. Anti-IL-1β drugs already approved include rilonacept and canakinumab.

Immunopaedia Case Studies Links
A case of cough, wasting and lymphadenopathy
A case of lymphadenopathy and night sweats

Immunopaedia Case Studies Links

A case of cough, wasting and lymphadenopathy

A case of lymphadenopathy and night sweats