IL-1α

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Ligands
IL-1α (Human)

GtoPdb Ligand ID: 4973

Synonyms: hematopoietin-1 | interleukin-1 alpha

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-1α is an IL-1 family cytokine.

Species: Human

References
1. Hong DS, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, Stecher M, Mohanty P et al.. (2015) Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer. Invest New Drugs, 33 (3): 621-31. [PMID:25822109]
2. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015) Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs, 7 (3): 605-19. [PMID:25764208]
3. Simard J. (2009) Interleukin-1 alpha abs and methods of use. Patent number: WO2009148575 A1. Assignee: Xbiotech, Inc.. Priority date: 30/05/2008. Publication date: 10/12/2009.

References

1. Hong DS, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, Stecher M, Mohanty P et al.. (2015)
Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer.
Invest New Drugs, 33 (3): 621-31. [PMID:25822109]

2. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015)
Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.
MAbs, 7 (3): 605-19. [PMID:25764208]

3. Simard J. (2009)
Interleukin-1 alpha abs and methods of use.
Patent number: WO2009148575 A1. Assignee: Xbiotech, Inc.. Priority date: 30/05/2008. Publication date: 10/12/2009.