- Guide to PHARMACOLOGY
Synonyms: hematopoietin-1 | interleukin-1 alpha
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-1α is an IL-1 family cytokine.
|The IL-1α precursor can bind and activate its receptor. It is pro-inflammatory.
An anti-IL-1α antibody called MABp1 (bermekimab, trade name Xilonix) was developed by XBiotech as an anticancer therapeutic . However, a Phase 3 study in colorectal cancer patients (NCT01767857) was terminated due to a lack of efficacy.