IFN-α1/13

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Ligands
IFN-α1/13 (Human)

GtoPdb Ligand ID: 4955

Synonyms: IFN-α1 | IFN-α13 | IFN-alpha 1/13 | interferon alpha-1/13 | interferon alpha-D

Compound class: Endogenous peptide in human, mouse or rat

Comment: Interferon-αs are type I IFNs (includes IFNαs, IFN-β, IFN-ε, IFN-κ and IFN-ω). In humans, there are 13 different IFN-α genes , but only 12 functional human IFN-α proteins, since IFN-α1 and IFN-α13 have identical protein sequences despite being encoded by separate genes.

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

References
1. Maurer B, Bosanac I, Shia S, Kwong M, Corpuz R, Vandlen R, Schmidt K, Eigenbrot C. (2015) Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab. Protein Sci, 24 (9): 1440-50. [PMID:26099203]
2. Witte A, Williams D, Cardarelli JM, King D, Passmore D. (2010) Anti-interferon Alpha Antibodies. Patent number: US7741449. Assignee: Medarex, Inc.. Priority date: 10/12/2003. Publication date: 22/06/2010.

References

1. Maurer B, Bosanac I, Shia S, Kwong M, Corpuz R, Vandlen R, Schmidt K, Eigenbrot C. (2015)
Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab.
Protein Sci, 24 (9): 1440-50. [PMID:26099203]

2. Witte A, Williams D, Cardarelli JM, King D, Passmore D. (2010)
Anti-interferon Alpha Antibodies.
Patent number: US7741449. Assignee: Medarex, Inc.. Priority date: 10/12/2003. Publication date: 22/06/2010.