- Guide to PHARMACOLOGY
Synonyms: CI-719 | Gen-Fibro® | Jezil®
gemfibrozil is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Gemfibrozil is a fibric acid antilipemic agent, pharmacologically similar to clofibrate.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: gemfibrozil
1. De Filippis B, Giancristofaro A, Ammazzalorso A, D'Angelo A, Fantacuzzi M, Giampietro L, Maccallini C, Petruzzelli M, Amoroso R. (2011)
Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism.
Eur J Med Chem, 46 (10): 5218-24. [PMID:21889235]
2. Noé J, Portmann R, Brun ME, Funk C. (2007)
Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.
Drug Metab Dispos, 35 (8): 1308-14. [PMID:17470528]